meto-revive

Roughly one in six men will be diagnosed with prostate cancer at some point in their lives, but these cancers usually aren’t life-threatening. Most newly diagnosed men have Grade Group 1 (GG1) prostate cancer, which can linger for years without causing significant harms.

Prostate cancer is categorized according to how far it has spread and how aggressive it looks under the microscope. Pure GG1 prostate cancer is the least risky form of the disease. It occurs frequently with age, will not metastasize to other parts of the body, and it doesn’t require any immediate treatment.

So, should we even call it cancer? Many experts say no.

Dr. Matthew Cooperberg, who chairs the department of urology at the University of California, San Francisco, says men wouldn’t suffer as much anxiety — and would be less inclined to pursue unneeded therapies — if their doctors stopped referring to low-grade changes in the prostate as cancer. He recently co-chaired a symposium where experts from around the world gathered to discuss the pros and cons of giving GG1 cancer another name.

Treatment discrepancies

GG1 cancer is typically revealed by PSA screening. The goal with screening is to find more aggressive prostate cancer while it’s still curable, yet these efforts often detect GG1 cancer incidentally. Attendees at the symposium agreed that GG1 disease should be managed with active surveillance. With this standard practice, doctors monitor the disease with periodic PSA checks, biopsies, and imaging, and treat the disease only if it shows signs of progression.

But even as medical groups work to promote active surveillance, 40% of men with low-risk prostate cancer in the United States are treated immediately. According to Dr. Cooperberg, that’s in part because the word “cancer” has such a strong emotional impact. “It resonates with people as something that spreads and kills,” he says. “No matter how much we try to get the message out there that GG1 cancer is not an immediate concern, there’s a lot of anxiety associated with a ‘C-word’ diagnosis.”

A consequence is widespread overtreatment, with tens of thousands of men needlessly suffering side effects from surgery or radiation every year. A cancer diagnosis has other harmful consequences: studies reveal negative effects on relationships and employment as well as “someone’s ability to get life insurance,” Dr. Cooperberg says. “It can affect health insurance rates.”

Debate about renaming

Experts at the symposium proposed that GG1 cancer could be referred to instead as acinar neoplasm, which is an abnormal but nonlethal growth in tissue. Skeptics expressed a concern that patients might not stick with active surveillance if they aren’t told they have cancer. But should men be scared into complying with appropriate monitoring? Dr. Cooperberg argues that patients with pure GG1 “should not be burdened with a cancer diagnosis that has zero capacity to harm them.”

Dr. Cooperberg does caution that since biopsies can potentially miss higher-grade cancer elsewhere in the prostate, monitoring the condition with active surveillance is crucial. Moreover, men with a strong family history of cancer, or genetic mutations such as BRCA1 and BRCA2 that put them at a higher risk of aggressive disease, should be followed more closely, he says.

Dr. Marc Garnick, the Gorman Brothers Professor of Medicine at Harvard Medical School and Beth Israel Deaconess Medical Center, and editor in chief of the Harvard Medical School Guide to Prostate Diseases, agrees. Dr. Garnick emphasized that a name change for GG1 cancer needs to consider a wide spectrum of additional testing. “This decision can’t simply be based on pathology,” he says. “Biopsies only sample a miniscule portion of the prostate gland. Genetic and genomic tests can help us identify some low-risk cancers that might behave in a more aggressive fashion down the road.”

Meanwhile, support for a name change is gaining momentum. “Younger pathologists and urologists are especially likely to think this is a good idea,” Dr. Cooperberg says. “I think the name change is just a matter of time — in my view, we’ll get there eventually.”

About the Author

Charlie Schmidt, Editor, Harvard Medical School Annual Report on Prostate Diseases

Charlie Schmidt is an award-winning freelance science writer based in Portland, Maine. In addition to writing for Harvard Health Publishing, Charlie has written for Science magazine, the Journal of the National Cancer Institute, Environmental Health Perspectives, … See Full Bio View all posts by Charlie Schmidt

About the Reviewer

Marc B. Garnick, MD, Editor in Chief, Harvard Medical School Annual Report on Prostate Diseases; Editorial Advisory Board Member, Harvard Health Publishing

Dr. Marc B. Garnick is an internationally renowned expert in medical oncology and urologic cancer. A clinical professor of medicine at Harvard Medical School, he also maintains an active clinical practice at Beth Israel Deaconess Medical … See Full Bio View all posts by Marc B. Garnick, MD

Sexual violence occurs throughout the world. A simple definition is any sexual act for which consent is not obtained or freely given, according to the Centers for Disease Control and Prevention (CDC). Rape, sexual coercion, and unwanted sexual contact are a few examples.

While many people heal fully in time, traumatic events like these may contribute to long-lasting health issues such as heart disease, gastrointestinal disorders, and certain mental health conditions. Being aware of these possibilities can help you — and your health care clinicians, if you choose to share with them — identify and respond to health issues promptly.

Our trauma doesn’t have to define us. Knowing how to get proper treatment and support can help people who have experienced sexual violence live fulfilling, healthy lives.

Who is affected by sexual violence?

Statistics vary on different forms of sexual violence. One in four women and one in 26 men in the US report rape or attempted rape during their lifetime, for example.

Anyone can experience sexual violence. But it disproportionately impacts certain groups, such as women, people who are racially or ethnically marginalized or who identify as LGBTQ+, and people with low incomes.

Possible emotional effects of sexual violence: What to know

Most people who experience sexual assault report that it affects their mental health. Depression and anxiety are very common after sexual assault. So is post-traumatic stress disorder (PTSD). A review of multiple studies estimates that 75% of people have symptoms of PTSD within a month of the incident, and about 40% continue to have PTSD one year after the incident.

PTSD symptoms may include

• flashbacks
• distressing or intrusive memories or nightmares
• severe anxiety
• dissociation.

People with PTSD may feel numb, angry, helpless, or overwhelmed. They may also avoid triggers that remind them of the traumatic event, like certain places, smells, or objects.

Remember, your mental health is an important part of your overall health and well-being. Consider finding or asking for a referral for a mental health specialist who specializes in trauma-focused psychotherapy. This might include cognitive processing therapy, exposure-based therapy, or eye movement desensitization and reprocessing (EMDR) therapy.

Possible health effects following sexual violence: What to know

Sexual violence can have immediate health effects, of course, and reaching out to get help is important.

Yet weeks, months, or even years later, some — though not all — people develop health issues related to their trauma. Research suggests sexual violence may increase risk for some chronic health conditions, such as

• heart disease
• diabetes
• high blood pressure
• chronic pain, including pelvic pain
• frequent headaches or migraines
• irritable bowel syndrome
• substance use disorder, including opiate use.

Seeking treatment can support your healing and well-being. Consider talking to your health care provider if you think you may be experiencing any of these symptoms or conditions.

How do I talk to my doctor about my history of sexual assault?

It’s important to feel safe and comfortable with your health provider. Here are four helpful tips to consider when seeking health care:

• Ask about trauma-informed care. While sometimes your choice of provider is limited, you may be able to ask to see a clinician who provides trauma-informed care. Trauma-informed care acknowledges how trauma impacts our health and promotes an individual’s sense of safety and control.
• Share as little or as much as you like. If you’re comfortable, you can tell your clinician you have a history of sexual assault or trauma. It is your choice whether you want to discuss your trauma history with your health professional. If you choose not to, you can still seek care for any health issues related to your sexual assault. This is a confidential part of your medical record, like any other part of your medical history.
• Starting a conversation. If you decide to share, you can start the conversation with one of these examples:
  • “I want you to know I have a history of trauma.”
  • “My trauma continues to affect my health today in [insert ways].”

If the provider asks follow-up questions about your traumatic experience, know that you can provide as little or as much detail as you feel comfortable sharing.

• Medical record confidentiality. Ask if your health care institution provides any extra levels of confidentiality for your medical record. Sometimes, this includes additional access restrictions or passwords to enter your health record. This can be especially important if you have an abusive partner, or another person that you are concerned will try to inappropriately gain access to your medical records.

How can you prepare for a physical exam and talk to a clinician?

• Know that you have choices. A physical exam may help you get care you want or need to address a health issue. Yet sometimes people who have been sexually assaulted find physical exams stressful, difficult, or even traumatic. If your clinician would like to perform a physical exam, know that you can always decline or schedule it for another day or time.
• Consider having a support person present. Sometimes a support person like a good friend may make you more comfortable during your visit or exam. You can also ask the provider to have a second staff member in the room, and request a gender preference.
• Ask the provider to explain things before each step. Before the exam, you can ask the clinician to make sure you understand the steps of the exam. Remember, you can choose to pause or stop the exam at any time.
• Your consent matters. No matter the setting, you always have the right to decide how and when your body is examined and/or touched. All health care providers are held to professional and ethical standards to protect your rights. If a clinician violates this, you have the right to report the incident to the health care employer and/or local law enforcement, and to seek care elsewhere.

A few final thoughts

Sexual violence is never okay under any circumstances. If this has happened to you, know that it is not your fault.

Traumatic experiences like sexual assault can affect the body and mind. They may increase the risk of long-term health issues such as PTSD, depression, substance use disorder, high blood pressure, and chronic pelvic pain. Yet all health conditions related to sexual assault can be effectively treated. And most people who experience trauma heal and go on to live meaningful, fulfilling lives.

About the Author

Rose McKeon Olson, MD, MPH, Contributor

Dr. Rose McKeon Olson is an associate physician in the department of medicine at Brigham and Women’s Hospital, and an instructor of medicine at Harvard Medical School. She has special research interests in trauma-informed care and … See Full Bio View all posts by Rose McKeon Olson, MD, MPH